BLOOD CLEARANCE OF <99m>Tc-PHYTATE FOR EVALUATION OF HEPATIC DYSFUNCTION IN DOGS
Keywords:
dog
1988 Volume 13 Issue 3 Pages 151-159
Details
1988 Volume 13 Issue 3 Pages 151-159
Organ distribution pattern, and blood clearance were examined by giving <99m>Tc-phytate (<99m>Tc-P) to the normal dogs. At the same time, the relation between the severity of hepatic function and blood clearance of <99m>Tc-P was studied by using the dogs with acute hepatic dysfunction experimentally induced by carbon tetrachloride (CCl4) administration. Furthermore, a comparative discussion on blood clearance test of <99m>Tc-p was made with serum transaminase test. It appeared appropriate to administer <99m>Tc-P at the dose of 100 μg/kg in order to obtain an effective blood clearance curve. A major part of <<99m<Tc-p intravenously administered was taken up into the liver, while the remainder of small amount into the spleen, kidneys, lung, and so on. Little was recognized in the thyroid. The disappearance rate of <99m>Tc-P from blood decreased with the increase in dose of CCl4 and with the passage of time after the CCl4 administration. The blood clearance test of <99m>Tc-P in dogs showed a sensitive reaction for the acute hepatic dysfunction induced by CCl4 equally to the serum transaminase test.
