Abstract
The effect of α-naphthylisothiocyanate (ANIT) on blood clearance of <99m>Tc-phytate (<99m>Tc-P) in rats was examined, and blood clearance test of <99m>Tc-P was compared with the cases of serum transaminase test, serum bilirubin test or histological test of the liver. The disappearance rate of <99m>Tc-P from blood decreased with the increase in dose of ANIT and with the passage of time after the ANIT administration. Changes of the blood clearance of <99m>Tc-P after ANIT treatment in rats may be influenced by the disorder in the hepatocytes rather than in the bile ductule cells. The blood clearance test of <99m>Tc-P in rats showed a sensitive reaction for the acute hepatic dysfunction induced by ANIT equally to the serum transaminase test, the serum bilirubin test or the histological test of the liver.
