LONG TERM ORAL ADMINISTRATION STUDY OF PRAVASTATIN SODIUM TO BEAGLES FOR 104 WEEKS

Abstract

Pravastatin sodium was successively given for 104 weeks to beagles orally at doses of 5 and 25mg/kg/day. A decrease in serum cholesterol levels was observed at week 4 and thereafter. No other abnormal findings were obtained in any animals in general conditions, hematological and biochemical examinationd, various function tests, and pathological examinations. The no-effect dose level in beagles receiving pravastatin sbdium orally for 104 weeks is toxicologically estimated to be more than 25mg/kg/day.