The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
OXYGEN DEPENDENCE OF LIPID PEROXIDATION IN MICE
Yoshihiro YOSHIMURAKatsumi UCHIYAMAKeiko OHSAWAKazuo IMAEDAYoshiki OHTANIKohei TAMURA
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Keywords: tissue damage
JOURNAL FREE ACCESS

1991 Volume 16 Issue 1 Pages 1-9

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Abstract

Peroxidation of lipids in serum and tissues of mice placed in low or high levels of oxygen was examined. After exposure to 100% oxygen for 3h, no significant differences were observed between control and exposed mice. However, exposure to 100% oxygen for 6h resulted in a decrease in oxygen consumption, an increase in lipid peroxides in tissues and serum, and the formation of hydroxyl radicals in tissues and serum. At low concentrations of oxygen (14% or 16%), a decrease in oxygen consumption, peroxidation of lipids and formation of hydroxyl radicals also were observed. Damage to mice was great with the lower oxygen concentrations of oxygen. There was a close correlation between the consumption of oxygen lipid peroxidation, formation of hydroxyl radicals.

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