Author's Organization：
Department of Pharmacology, School of Medicine, Keio University
Safety of Medicines Department, ZENECA Pharmaceuticals
Developmental Research Laboratories, Daiichi Pharmaceutical Co., Ltd.
Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
Department of Safety Research, Eisai Co., Ltd.
Department of Toxicology & Pathology, Nippon Roche Research Center
Drug Safety Reserch Laboratories, Takeda Chemical Industry
Department of Durg Metabolism and Pharmacokinetics, Schering-Plough Institute
Clinical Investigation, McNeil Pharmaceutical, Spring House
Department of R & D Information Technology, Eisai Co., Ltd.