AN ACUTE TOXICITY STUDY OF RECOMBINANT HUMAN INTERFERON αA (LBD-007) IN SPRAGUE-DAWLEY RATS

Abstract

The acute toxicity of a recombinant human interferon αA (code name: LBD-007) was evaluated in both sexes of Sprague-Dawley rats, 5 weeks old, by the oral, subcutaneous and intravenous routes of administration. Based on the results, LBD-007was not considered to induce any toxicological effect on the rats in mortalities, clinical findings, body weights and gross findings. It is suggested that LD_&lt50&gt values in rats would be &gt48×10⁸ IU/kg in the study of oral administration and &gt24×10⁸ IU/kg in the study of subcutaneous or intravenous administration.