Abstract
The acute toxicity of a recombinant human interferon αA (code name: LBD-007) was evaluated in both sexes of Sprague-Dawley rats, 5 weeks old, by the oral, subcutaneous and intravenous routes of administration. Based on the results, LBD-007was not considered to induce any toxicological effect on the rats in mortalities, clinical findings, body weights and gross findings. It is suggested that LD<50> values in rats would be >48×108 IU/kg in the study of oral administration and >24×108 IU/kg in the study of subcutaneous or intravenous administration.
