Abstract
The course of the sleeping time response after a single injection of p, p'-DDE was investigated in rats. The concentrations of p, p'-DDE in tissues after the sleeping time respense had returned to the original control level were also determined. Sleeping time response were somewhat dependent on p, p'-DDE dose level. Considerable amounts of p, p'-DDE were found in fat, liver and serum even after sleeping time response had returned to the control level. Using the experimental data, the biological half lives of p, p'-DDE in tissues was estimated. The concentrations of p, p'-DDE in liver, fat and serum just after the sleeping time had returned to the control level were also estimated.
