抄録
Hepatic injury and hepato-accumulation of (+)rugulosin, an anthraquinoid mycotoxin from Renicillium rugulosum Thom, were investigated in mice. Subcutaneously administered (+) rugulosin to ddYS mice induced an elevation of glutamate-poxaloacetate transaminase in the serum, a depression of mitochondrial function and an accumulation of monoribosomes in the liver. Tracer experiments revealed that the administered toxin preferencially accumulated into the liver, especially into the mitochondrial and microsomal fractions. Lethal toxicity test as well biochemical assay revealed that (+) rugulosin is a slow acting hepatotoxin.
