The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
DEPLETION OF GLUTATHIONE AND HEPATO-TOXICITY CAUSED BY VINYL ETHERS IN MICE
Masakazu ISOBETomomichi SONEEigo TAKABATAKE
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Keywords: Hepatotoxicity
JOURNALS FREE ACCESS

1995 Volume 20 Issue 2 Pages 161-164

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Abstract

4-Nitrophenyl vinyl ether (NPVE) and phenyl vinyl ether (PVE) administered i.p. in mice lowered hepatic non-protein sulfhydryl (NP-SH) content, but did not elevate the serum glutamate pyruvate transaminase (GPT) activity. n-Butyl vinyl ether (BVE) showed no significant effects either on the NP-SH content or on the serum GPT activity. Mice pretreated with buthionine sulfoximine were sensitive to the potential toxicity of NPVE. These results showed that aryl vinyl ethers, NPVE and PVE, are more toxic than the alkyl vinyl ether, BVE, and that glutathione plays an important role on the protection of hepatic injury by reactive metabolite(s) derived from vinyl ethers.

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