DERMATOTOXICITY STUDIES OF CALCIPOTRIOL (MC903) OINTMENT : Primary Skin Irritation, Skin Sensitization, Phototoxicity and Skin Photosensitization

Toshiro SUZUKI; Toshihiro KATO; Tadahatu KITAGAKI; Masahiro ONO; Kiyomi SHIRAKAWA; Mitsuhiro NAGATA; Ryoji KONISHI

doi:10.2131/jts.21.SupplementII_475

Toshiro SUZUKI, Toshihiro KATO, Tadahatu KITAGAKI, Masahiro ONO, Kiyomi SHIRAKAWA, Mitsuhiro NAGATA, Ryoji KONISHI

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Keywords: Skin photosensitization (rabbit, guinea-pig)

JOURNAL FREE ACCESS

1996 Volume 21 Issue SupplementII Pages 475-484

DOI https://doi.org/10.2131/jts.21.SupplementII_475

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Abstract

MC903 ointment was studied on primary skin irritation in rabbits and skin sensitization, skin photosensitization and phototoxicity in guinea-pigs. 1. MC903 ointment, ointment base and deteriorated MC903 ointment induced erythematous changes in rabbit skin. These erythematous changes were not so serious, and they were classified as a mild irritant. 2. MC903 ointment was almost negative in skin sensitization study. 3. MC903 ointment has no skin phototoxicity in guinea-pigs. 4. MC903 ointment has no skin photosensitizing activity in guinea-pigs.

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