REVERSE MUTATION TEST OF DISODIUM MERCAPTOUNDECAHYDRO-CLOSO-DODECABORATE WITH BACTERIA

Abstract

Disodium mercaptoundecahydro-closo-dodecaborate (BSH) was studied for mutgenic potential by reverse mutation test with bacteria. The test was carried out using five different tester strains, S.typhimurium TA100, TA1535, TA98 and TA1537, and E.coli WP2uvrA by the preincubation method. BSH was tested at concentrations ranging from 156 to 5000 μg per plate. The test substance did not induce revertants dose-dependently in any strains with or without a metabolic activation system. Therefore, it was concluded that BSH was not mutagenic in the present reverse mutation test.