The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
SKIN TOXICITY OF PROPRANOLOL IN GUINEA PIGS
Ichiro KOBAYASHIKyoko HOSAKAHiroki MARUOYuji SAEKIMasashi KAMIYAMAChohachi KONNOMunekazu GEMBA
著者情報
キーワード: Photo sensitization
ジャーナル フリー

1999 年 24 巻 2 号 p. 103-112

詳細
抄録
The skin toxicities of propranolol were studied in guinea pigs. In the primary and cumulative skin irritation studies, the skin reactions and the histopathological changes were observed in all animals treated with propranolol, and those tended to increase with the increase of propranolol dosage. The skin reactions increased with the application times of propranolol up to 7 days in the cumulative skin irritation study. In the skin sensitization, the phototoxicity and the skin photosensitization studies, no skin reactions were observed in any animals used in the studies. These results indicate that propranolol caused skin irritation, but was negative for skin sensitization, phototoxicity and skin photosensitization in guinea Pigs.
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© The Japanese Society of Toxicology Headquarters
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