The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
NOVEL ACTION OF QUINOLONES ON OSTEOCLAST-LIKE CELLS
Nobuyuki FUKUISHINobuaki MATSUIReiko KANOHMasaaki AKAGI
Author information
Keywords: Toxicity
JOURNALS FREE ACCESS

1999 Volume 24 Issue 5 Pages 383-391

Details
Abstract

Quinolones have a broad antibacterial spectrum against Gram-negative and Gram-positive bacteria. The compounds, however, have a few adverse effects, such as convulsion and toxicity to articular cartilage. We observed that some quinolones such as Naldixic acid, Ofloxacin, and Norfloxacin have osteoclast-inducing effects. All quinolones we tested produced tumor necrosis factor-alpha and prostaglandin E2, and have potency as osteoclast inducers to cultured cells. These results suggest that some quinolones affect osteoclast induction or activation, and this may be related to the production of tumor necrosis factor-alpha (TNF-alpha) and prostaglandin E2 (PGE2).

Information related to the author
© The Japanese Society of Toxicology Headquarters
Previous article Next article
feedback
Top