MUTAGENICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (3) : MICRONUCLEUS TEST IN RAT BONE MARROW CELLS

Naoki TORITSUKA; Hirohiko DAIMON; Shigeki SAWADA; Fumio SAGAMI; Piero TIRONE; Alberto MORISETTI; Simona BUSSI; Franca FASSIO

doi:10.2131/jts.24.SupplementI_103

Naoki TORITSUKA, Hirohiko DAIMON, Shigeki SAWADA, Fumio SAGAMI, Piero TIRONE, Alberto MORISETTI, Simona BUSSI, Franca FASSIO

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Keywords: Mutagenicity

JOURNAL FREE ACCESS

1999 Volume 24 Issue SupplementI Pages 103-106

DOI https://doi.org/10.2131/jts.24.SupplementI_103

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Abstract

The mutagenic potential of gadobenate dimeglumine formulation (E7155) was studied by the micronucleus test in rats. Single intraperitoneal injection of E7155 to Sprague Dawley rats at the dose of 5295.2 mg/kg (5 mmol/kg) did not induce any statistically significant increase in the frequency of micronucleate cells in the bone marrow sampled after 18, 42 and 66 hr from time of administration.

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