IMPAIRMENTS OF GLYCOGEN AND DRUG METADOLISMS BY CHLOROPEPTIDE, A HEPATOTOXIC MYCOTOXIN OF PENICILLIUM ISLANDICUM SOPP

Abstract

Administration of chloropeptide, a hepatotoxic cyclic pentapeptide of Penicillium islandicum Sopp, caused a marked decline in the hepatic glycogen synthetase activity with concominant increase in NADP-dependent G-6-P dehydrogenase activity. The microsomalmixed function oxygenases were also reduced in the liver of rats following chloropeptide treatment.