著者所属：Department of Microbial Chemistry and Toxicology, Faculty of Pharmaceutical Sciences, Tokyo University of Science Department of Microbial Chemistry and Toxicology, Faculty of Pharmaceutical Sciences, Tokyo University of Science Department of Carcinogenicity and Cancer Susceptibility, Institute of Medical Sciences, University of Tokyo
Administration of chloropeptide, a hepatotoxic cyclic pentapeptide of Penicillium islandicum Sopp, caused a marked decline in the hepatic glycogen synthetase activity with concominant increase in NADP-dependent G-6-P dehydrogenase activity. The microsomalmixed function oxygenases were also reduced in the liver of rats following chloropeptide treatment.
