The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
REPRODUCTION STUDY OF CARTEOLOL HYDROCHLORIDE IN MICE. PART 2. PERI- AND POSTNATAL TOXICITY.
Minoru TAMAGAWAToyoko NUMOTONobuyuki TANAKAHiroshi NISHINO
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1979 Volume 4 Issue 1 Pages 59-77_2

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Abstract

Carteolol was orally administered to mice once a day at doses of 3, 30 and 150 mg/kg/day during the perinatal and lactation periods and evaluated on its adverse effects on pregnant animals and their offspring. No appreciably abnormal findings related to the drug administration were revealed. Therefore, it was concluded that carteolol have no serious toxic potential on parturition and lactation by mother animals, no adverse effects on growth and development, and behavioral and reproductive performance of offspring and no carcinogenic action through placental and milk transfer.

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