INFLUENCE OF 6α-METHYLPREDNISOLONE 21-SODIUM SUCCINATE ON THE PITUITARY, ADRENAL GLANDS, AND THE GASTRO-INTESTINAL TRACT IN RATS. : (COMPARATIVE TOXICITY STUDY WITH HYDROCORTISONE 21-SODIUM SUCCINATE)

Abstract

A comparative toxicity study with 6α-methylprednisolone 21-sodium succinate and hydrocortisone 21-sodium succinate in male rats revealed that the inhibiting effect of these two steroids on the pituitary-adrenal system was the same. No ulceration was observed in the gastro-intestinal tract of rats treated with these compounds.