EFFECT OF METHYL BROMIDE ON CULTURED MAMMALIAN CELLS

Abstract

Cytotioxicity of methyl bromide on cultured mammalian cells was examined. Lethal concentrations of methyl bromide on HeLa cells and primary cultured muscle, kidney and brain cells were similar (10 μg/ml). Acute toxic effect was induced by methyl bromide itself. And its cytotoxicity was reduced in the presence of glutathione. The action of methyl bromide seemed to be nonspecific protoplasm-toxic.