1981 Volume 6 Issue 2 Pages 105-113
The subcutaneous administration of chloropeptide, a hepatotoxic cyclic pentapeptide of Penicillium islandicum Sopp, induced a marked enlargement of hepatic weight in mice. Chemical analysis revealed an increment of water content. Biochemical investigation resulted in marked elevation of serum enzyme activities such as transaminases, alcohol dehydrogenase, fructose-1-phosphate aldolase and lactate dehydrogenase.