ORAL ACUTE TOXICITY WITH STIMULANTS AND BLOCKERS OF BETA-ADRENOCEPTORS IN SINGLY-HOUSED OR AGGREGATED MICE

Abstract

Acute oral toxicity of the three Beta-adrenoceptor stimulants Orciprenalin, Fenoterol and Salbutamol as well as the two Beta-adrenoceptor blockers Pindolol and Bunitrolol was studied in singly-housed and aggregated male and female mice (ICR-JCL) and the results were compared with those in grouped mice (background studies). With a few exceptions, the acute toxic potency of the five test substance in mice appeared to be : Aggregated mice &gtgrouped mice &gt singly-housed mice.