Abstract
This report dealt with the effects of dimercaprol (BAL) and thiotic acid (TA), antidotes against arsenical, on the distribution and the excretion of <74>As in several organs of the rat. Each organ was removed and served for quantitative analysis of <74>As five days after subcutaneous injection of Na3<74>AsO3 5 μCi/100 g. Administration of BAL or TA was performed intraperitoneally with a single administration or five consecutive administrations for five days before animals were sacrificed. <74>As content in each organ of the rat decreased to a greater extent in the five consecutive administration group of BAL or TA than in the non-treated or single administration groups. Moreover, the excretion of <74>As in a digestive tract increased more remarkably in the five consecutive administration group than in the non-treated or single administration groups. There were no differences in the excretion or the content of <74>As in each organ between the single administration group and the non-treated group.
