SIMILARITY OF CHLOROPEPTIDE TO PHALLOIDIN IN TOXICITY TO ISOLATED HAPATOCYTES

Yoshio UENO; Yumiko TANAKA; Kensaku SATO; Katsuji SAKAKIBARA; Toshiaki TACHIBANA; Akira TANAKA

doi:10.2131/jts.9.117

Yoshio UENO, Yumiko TANAKA, Kensaku SATO, Katsuji SAKAKIBARA, Toshiaki TACHIBANA, Akira TANAKA

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Keywords: rifampicin

JOURNAL FREE ACCESS

1984 Volume 9 Issue 2 Pages 117-130

DOI https://doi.org/10.2131/jts.9.117

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Abstract

Chloropeptide, a hepatotoxic pentapeptide of Penicillium islandicum Sopp, induces deformation (blebbing or balooning) of the cytoplasmic membrane in the isolated rat hepatocytes, and this hepatotoxic feature is very similar to that of phalloidin.

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