2018 年 88 巻 Extra1 号 p. E27-E34
Since the 2010s, the methods of developing clinical practice guidelines have dramatically changed worldwide. In Japan, the Medical Information Network Distribution Service (Minds) released a new manual entitled, "Minds Manual for Clinical Practice Guideline Development" in 2014 that adopted the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. However, the practical personnel in charge of developing these guidelines often experience difficulties in using the Minds manual; for example, some items are difficult to fully understand by referring only to the manual and there are questions about how to handle those items in practice. Therefore, in this paper, we present the questions frequently received from practical personnel in the development of clinical practice guidelines as well as answers to them. The workflow for the development of clinical practice guidelines is as follows: 1. Preparation, 2. Scoping, 3. Systematic Review, 4. Recommendations, 5. Finalization, 6. Dissemination, Implementation, and Assessment of Clinical Practice Guidelines. This paper summarizes the questions and answers in line with this flow. In the development of clinical practice guidelines, transparency of the development process ensures unbiasedness (neutrality) of the guidelines that are created. This realizes the development of reliable clinical practice guidelines. On the other hand, the methods of developing clinical practice guidelines are changing worldwide. Please refer to the Minds website for the latest trends in the development of clinical practice guidelines.
