Transient neonatal pustular melanosis (TNPM) is characterized by aseptic pustules scattered throughout the body since birth, leaving pigmentation and resolving spontaneously. A few cases of TNPM have been reported in Japan, most of which were difficult to be differentially diagnosed and subsequently required therapeutic intervention such as topical treatment or the administration of antibiotics.
Herein, we report a case of a male infant weighing 3,206 g at 39 weeks of gestation who was presented with disseminated pustules throughout his body since birth. Blood tests and pustule culture tests on admission revealed no pustule formation owing to bacterial infection, leading to the suspicion of TNPM. From day 4 onward, the pustules gradually disappeared until day 9, with some pigmentation. Accordingly, TNPM was diagnosed. TNPM has a good prognosis that can be followed up without treatment. Nevertheless, neonatologists and pediatricians should be aware of TNPM.
