Abstract
Clinical observations were done on five patients who received incompatible blood trans fusions. Two of the incompatibilities were in the ABO system and three by the irregular antibodies that did not cause hemolysis in vitro (anti-E, anti-Jka and aniti-Jkb). In two of the ABO-incompatibility and one of the incompatibility by the anti-E antibody, bleeding tendencies such as oozing from the operative sites, vaginal bleeding, hematuria and bleeding from the venipuncture sites were observed following incompatible transfusions during or after surgery. Acute renal failure was also developed in one. She was positive in the anti-E antibody and received the administration of 1,000 ml of E-positive blood. Coagulation studies revealed evidence of disseminated intravascular coagulation (DIC) such as thrombocytopenia, marked elevation of FDP and decrease of plasminogen and antithrombin Ⅲ in these three patients. DIC may play an important role in the pathogenesis of hemolytic transfusion reaction not only in the ABO-incompatibility but also in the incompatibility caused by the irregular antibody.
