Journal of UOEH
Online ISSN : 2187-2864
Print ISSN : 0387-821X
ISSN-L : 0387-821X
Screening for Carcinogens by DNA-Synthesis Inhibition Test Using Mouse L-Cells
Sadao GOTOHYasuko MIYATAChiyoko NISHIKen HIGASHIYukiya SAKAMOTO
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1983 Volume 5 Issue 2 Pages 147-153

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Abstract
Bacterial test systems for potential carcinogens sometimes give false negative results. To overcome this problem, several short term test systems have been described. One of them is the DNA-synthesis inhibition test described by Painter(1977). Our DNA-synthesis inhibition test system using mouse L-cells gave positive results when monocrothaline, phenacetin and thioacetamide, which were negative in the Ames test, were tested.
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© 1983 The University of Occupational and Environmental Health, Japan
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