抄録
Ampicillin Na (AB-PC) was administered intravenously at a rate of 10 mg/kg/hr for 2 hours to the dogs anesthetized with halothane and enflurane, respectively. The AB-PC concentration reached the maximal values 2hours after the anesthesia (halothane 18.82 μg/ml, enflurane 19.57 μg/ml) which were approximately 1.4 times higher than that of the control dogs (13.84 μg/ml) . In addition, that the lower excretion rate was shown in the anesthetized dogs when terminating the drip infusion of AB-PC may indicate the depression of the excretion during anesthesia. The phenomena mentioned above are considered as the results caused by the deterioration of the blood-tissue permeation. Further study is necessary on the infusion method for maintaining AB-PC concentration during and after the operation.
