トセラニブ-メロキシカム併用療法のみで口咽頭扁平上皮癌が寛解した猫の1例

抄録

A 15-year-old neutered male domestic shorthair cat presented with a 2-month history of stridor, snoring, hoarseness, dysphagia and weight loss. Non- anesthetized contrast computed tomography of the head revealed a heterogeneous enhanced mass which was suspected as a malignant tumor the oropharynx, extending from the caudal soft palate. Fine needle aspiration under anesthesia was performed from deep tissue of the mass. Cytology revealed cells consistent with squamous cell carcinoma. The patient was treated with toceranib (10 mg/cat, p.o., EOD or thrice weekly) and meloxicam (0.025〜0.300 mg/kg, s.c. or p.o., SID, EOD or thrice weekly). Radiologically, the cancer resolved almost completely by day 8. The cancer recurred after 13 days of meloxicam suspension. Progression-free survival was 30 days. The range of creatinine was 1.83〜3.39 mg/dL during follow-up. This is the first reported case of an oropharyngeal squamous cell carcinoma in a cat treated with combinational therapy of toceranib and high dose meloxicam.