Abstract
A dog with multicentric lymphoma was treated with dexrazoxane to counteract adverse effects of doxorubicin extravasation. The leaked dose of doxorubicin was estimated to be approximately 2-3 mg. After 10 and 22 hrs of extravasation, 100 mg and 50 mg, respectively, of dexrazoxane was administered separately via the cephalic vein using a 24-G indwelling catheter under sedation. Additional treatment included local tissue cooling using ice packs. On day 7 after extravasation, no event was found in the skin, and no changes were seen in CBC and blood chemistry results compared with the previous week's results. On day 21, the extravasation site exhibited pigmentation without ulceration or necrosis. While the most effective dosage and timing of administration of dexrazoxane are not known, its use within 10 hrs can be effective in prevention of the adverse effects of doxorubicin extravasation, if the leaked amount of doxorubicin is small.
