Canine histiocytic sarcoma (HS) is a disease associated with hyperferritinemia, and the serum ferritin level is considered a useful tumor marker for HS. We expected the serum ferritin concentration to be related to the biological activity of HS and evaluated the change in serum ferritin levels during the treatment course for three cases of canine HS. The serum ferritin level in all three cases of HS decreased in the early period after chemotherapy, but then increased either immediately prior to or at the time of disease relapse. These results suggest that the serum ferritin concentration is a useful marker for monitoring the clinical course of HS.

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A dog with multicentric lymphoma was treated with dexrazoxane to counteract adverse effects of　doxorubicin extravasation. The leaked dose of doxorubicin was estimated to be approximately 2-3 mg. After 10 and 22 hrs of extravasation, 100 mg and 50 mg, respectively, of dexrazoxane was administered separately via the cephalic vein using a 24-G indwelling catheter under sedation. Additional treatment included local tissue cooling using ice packs. On day 7 after extravasation, no event was found in the skin, and no changes were seen in CBC and blood chemistry results compared with the previous week's results. On day 21, the extravasation site exhibited pigmentation without ulceration or necrosis. While the most effective dosage and timing of administration of dexrazoxane are not known, its use within 10 hrs can be effective in prevention of the adverse effects of doxorubicin extravasation, if the leaked amount of doxorubicin is small.

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A 9-year-old neutered female Miniature Dachshund had undergone lobectomy of the left frontal lobe for lung carcinoma followed by nine post-operative doses of carboplatin chemotherapy(250 mg/m², every 3weeks). The dog was referred to the Japan Animal Referral Medical Center (Nagoya), because of lung masses in the opposite right middle and posterior lobes. Whole body contrast-enhanced computed tomography(CT)was performed and revealed lung solitary tumors in the relevant areas. No abnormal findings were observed in other lobes or intrathoracic lymph nodes. Since the possibility of metastatic lesions of lung carcinoma incompletely removed in the previous surgery was considered, we performed CT again on day 45 for evaluation of the new tumor progression. The size of both tumors increased, and right middle and posterior lung lobectomies were carried out on day 53. There were no adhesive lesions around the tumors, carcinomatous pleuritis, pleural fluid or hilar lymphadenopathy. While histopathology revealed high-grade lung adenocarcinoma with numerous mitoses, there was no evidence of intravascular invasion, suggesting complete resection. A tentative diagnosis of metastatic lung tumor(T2N0M1)was made. Adjuvant chemotherapy with carboplatin(250 mg/m², for every 3 weeks)and piroxicam(0.3 mg/kg/3 days)was also given starting on day 21, and no evidence of recurrent lesions was observed on day 726 with a good health condition maintained. From these results, it is suggested that aggressive surgery plus adjuvant chemotherapy can be appropriate treatments for metastatic lung carcinoma.

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