Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
The Japanese Society of Small Animal Veterinary Medicine
Assessment of Neuological Function in Three Cats with Homozygous or Heterozygous GM1-Gangliosidosis by Brainstem Auditory Evoked Potential
Yasuaki KAWASAKIIkumi NAGATANIYoko TERASHIMAHitomi KOIKENobuaki MIYOSHIAkihiro OISHI
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2009 Volume 62 Issue 2 Pages 148-154

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Abstract

In a litter of three Japanese domestic short hair cats,two showed cerebellar ataxia,with decreased residual lysosomal β-galactosidase activity. Membranous cytoplasmic bodies were also observed electron microscopically in the medulla of the affected cats. The two cats were diagnosed with homozygous GM1-gangliosidosis,because the other cat without ataxia had intermediate residual enzyme activity between those in normal and affected cats,diagnosed with heterozygous GM1-gangliosidosis. In brainstem auditory evoked potential testing,the prolongation of peak latencies and the elevation of thresholds in waves I and V were observed in some cats. However, consistent abnormal findings observed in two affected cats included a fall in the amplitude ratio of wave I and V (I/V AR), which may imply conductive hearing loss, and a prolongation of the interpeak latency between wave I and V (I-V IPL),which reflects brainstem dysfunction. Brainstem function estimated by BAEP testing did not deteriorate with the stage of the disease, and higher brain function was not affected,although neurologic impairment such as central spontaneous nystagmus or swallowing difficulty progressed during the terminal stage.

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© 2009 Japan Veterinary Medical Association
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