In 2002，coliform cellulitis (Ce) in broiler chickens had occurred frequently in integrated broiler company A (Inte A). We investigated Ce condemnation rates in the processing plant and the gross lesion of Ce. In addition， we found coli-septicemia of serostitis (Se) with Ce on the farm， and compared it pathologically with Ce at the processing plant. Moreover，we investigated the causative factors of Ce compared with the integrated broiler company B (Inte B)， which has low condemnation rates of Ce. The Ce condemnation rate of Inte A was 0.88% and higher than that of Inte B (0.03%). Some 63% of condemned chickens by Ce were male，and showed evident thickening of the dermis， edema and the formation of a cheese-like clot under the skin of the abdominal region and the inside of the thigh，but did not show Se. Eschirichia coli serotype O78 was isolated from Ce lesions and Se lesions. The invasion of E coli serotype O78 into the skin from injuries was suspected，because the formation of escharosis and epidermal inflammations were identified in Ce in the farm cases. The strain of broiler chickens bred in Inte A was different from Inte B. Moreover，the breeding density of Inte A was higher， the period of heat dissipation was longer，and the period during which the chicken coop was empty was shorter than it was for Inte B.

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A total of 152 sows and gilts were clinically diagnosed as anestrus and their ovaries were observed by transrectal ultrasonography. Abnormal ovaries were depicted in 66 animals (43.4%)，and the remainder were normal. Feeding and management modification (adjustment of feed composition and volume with boar contact) was applied to 136 animals，except those with foot disease. In abnormal ovaries， eCG 1000IU was administered to ovarian quiescence (n=48) and GnRH-A 200μg to multiple ovarian cysts (n=2). Animals with normal ovarian findings (n=73) and oligo ovarian cysts with corpora lutea (n=13) were intact as control. As a result， the estrous return and conception ratio for the treated and control group were 96.0% vs. 98.8%， and 91.7% vs. 78.8%，respectively; (conception ratio : P<0.05). Both groups showed high estrous returns; however the conception ratio was low for the control. These results suggest that factors other than ovaries were considered in the conception ratio.

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Atlanto-occipital fusion was found in a three-year-old Holstein cow that died of heart failure. The atlas had a large，vertebral body， fused with a basal part of the occipital bone. No occipital condyle was not recognized. In the atlanto-axial joint， no dens was observed in the axis. From these findings， it was considered that the vertebral body remained in the atlas due to a failure to divide at the dens. This is a rare instance for an adult cow.

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The authors investigated whether Hsp70 deficiency，which is a genetic disease occurring in Holstein cows，can cause abomasal displacement in Holstein cows. The subjects were 495 multiparous Holstein cows raised in the Nemuro district of Hokkaido，and had developed abomasal displacement，receiving surgery to reposition the displaced abomasum. For genetic analysis，genotypes were classified into homozygous， heterozygous， and normal by PCR using peripheral blood and hair samples. Sixty cows had a mutation in the gene encoding Hsp70; one cow was homozygous (deficient) and 59 were heterozygous (carriers). The frequency of occurrence of mutations in the Hsp70 gene was calculated as 0.0616. A comparison of this value with the results of an investigation into the Hsp70 mutation between the normal group，at 0.0986，and the survey one revealed a significant difference. We concluded that there was no relationship between Hsp70 deficiency and abomasal displacement.

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Microbiological and histopathological examinations were carried out on five dead cockatiels ranging in age from one to two months，while oral swabs were taken from four live cockatiels with cockatiel lockjaw syndrome. Multiple bacterial agents were isolated from the lungs and from swabs of the nasal passage and oral cavity. Bordetella avium was isolated from five of the nine cockatiels. All isolates possessed a dermonecrotic toxin gene，which is thought to be responsible for pathogenicity. Histologically，skeletal muscles within the temporomandibular region showed denaturation and necrosis. Necrotic muscle fibers were organized by proliferated fibroblasts. Moderate to severe infiltrations of inflammatory cells and clusters of bacteria were observed. The antimicrobial susceptibility of B. avium isolates was investigated. The isolates were highly sensitive to common veterinary antibiotics such as beta-lactams，aminoglycosides and tetracyclines.

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In a litter of three Japanese domestic short hair cats，two showed cerebellar ataxia，with decreased residual lysosomaｌ β-galactosidase activity. Membranous cytoplasmic bodies were also observed electron microscopically in the medulla of the affected cats. The two cats were diagnosed with homozygous GM₁-gangliosidosis，because the other cat without ataxia had intermediate residual enzyme activity between those in normal and affected cats，diagnosed with heterozygous GM₁-gangliosidosis. In brainstem auditory evoked potential testing，the prolongation of peak latencies and the elevation of thresholds in waves I and V were observed in some cats. However， consistent abnormal findings observed in two affected cats included a fall in the amplitude ratio of wave I and V (I/V AR)， which may imply conductive hearing loss， and a prolongation of the interpeak latency between wave I and V (I-V IPL)，which reflects brainstem dysfunction. Brainstem function estimated by BAEP testing did not deteriorate with the stage of the disease， and higher brain function was not affected，although neurologic impairment such as central spontaneous nystagmus or swallowing difficulty progressed during the terminal stage.

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Seven striped dolphins (Stenella coeruleoalba) were found dead， stranded on Gogo island， Ehime， Japan in March 2003. A post-mortem examination of six of the seven adult dolphins demonstrated severe congestive edema of the lung. No signs of bruising or other trauma were observed. The possible causes of the mass stranding were not identified. Cystic enlargement of the follicles of the thyroid gland with an accumulation of abundant colloid were observed in two animals : these findings were consistent with goiter. An analysis of organohalogens in blubber showed a similar pattern of accumulation of organohalogens in marine mammals in Japan. In addition，high levels of organohalogens were detected.

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