Abstract
An 8-year-old spayed female Papillon was referred with depression, anorexia, and acute diarrhea. The dog had been diagnosed with megaesophagus and hypothyroidism 10 months earlier and had recovered with levothyroxine sodium. At this time, a serum biochemical profile showed hypoproteinemia and hypoglycemia.A diagnosis of primary adrenocortical insufficiency was established based on the results of an adrenocorticotropic hormone (ACTH) stimulation test and endogenous plasma ACTH determination. Since the electrolyte levels were normal, the dog was diagnosed as having atypical hypoadrenocorticism. The dog responded well to prednisolone therapy. The combination of primary hypothyroidism and hypoadrenocorticism suggests autoimmune polyendocrinopathy.
