Abstract
A 12-year-old male neutered mixed breed dog presented with left forelimb lameness and lethargy. Peripheral blood cytology revealed the presence of blastic cells, and bone marrow and spleen cytopathology showed neoplastic cells that were suspected megakaryocyte-derived cells. Flow cytometry revealed frequent platelet- and megakaryocyte-derived cells that were positive for CD41/61, markers for megakaryocytic precursors. The present case was therefore diagnosed as acute megakaryoblastic leukemia. Although the dogʼs general condition improved with prednisolone treatment, it developed acute anemia and thrombocytopenia, and subsequently died 26 days after admission, despite L-asparaginase and blood transfusion treatments.
