Abstract
White masses were detected in the lungs and abdominal and thoracic lymph nodes of a 63-month-old-female Holstein cow in a meat inspection. Following a cytological examination, sarcoma with multinucleated giant cells was diagnosed using the stamp-smear method. Histopathological examination revealed that the tumor comprised a predominant proliferation of small round neoplastic cells with scattered myoblast- or myotube-like neoplastic cells. Thus, it was diagnosed as an embryonal rhabdomyosarcoma. Immunohistochemical analysis revealed that the neoplastic cells were positive for vimentin and desmin, the predominant small round neoplastic cells were positive for MyoD1, while the neoplastic cells with striated muscle differentiation were positive for myogenin. The present case is a rare form of bovine embryonal rhabdomyosarcoma. Moreover, multinucleated giant cells corresponding to the myotube-like neoplastic cells in the histopathological specimens were detected in the stamp smear.
