2019 Volume 72 Issue 4 Pages 215-221
Feline polycystic kidney disease, an autosomal dominant genetic disease (fADPKD), has clinical presentations similar to humans. Clinicopathological features of fADPKD were described associated with hepatic cysts in three cats. In addition, histological examination of cystic livers and analysis of the cystic fluid were performed. All three cases were male Persian and Persian breed-related cats. Localized multilocular hepatic cysts in two cats and a large solitary hepatic cyst in one cat were observed. Grossly visible multilocular hepatic cysts were mostly located in the peripheral portions of hepatic lobules. Microscopic cysts were also observed in the parenchyma of the liver. These hepatic cysts were lined by a single layer of low cuboidal epithelial cells. The hepatic cystic fluid had higher potassium and urea concentrations, but similar sodium, chloride, and creatinine concentrations when compared to serum. No blood test findings suggested decreased liver function.
