T-cell Large Granular Lymphocytic Lymphoma in Young Dog

Abstract

A 1-year-8-month-old, mixed-breed dog presented with anorexia and diarrhea. Diagnostic imaging revealed abdominal masses, which were diagnosed as T-cell large granular lymphocyte (LGL) lymphoma by cytological and clonality examination. Multidrug therapy was ineffective. The dog died 14 days after the initial examination. Necropsy with histopathological and immunohistochemical examination revealed T-cell lymphoma involving systemic organs including mesenteric mass, liver, spleen, lungs, left and right kidneys, gastrointestinal tract, adrenal gland, mediastinum and lliac nodes.