Abstract
Bithionol (2, 2'-dihydroxy-3, 3'-5, 5'-tetrachlorodiphenylsulfide) and dichlorophen (5, 5'-dichloro-2, 2'-dihydroxy-diphenyl-methane) were tested for teniacidal action on tapeworms of the ruminant, Moniezia expansa and Moniezia benedeni.
Both chemicals were proved to be more effective against M. expansa than kamala. Although kamala showed cure rates varying from 23.3 to 78, 26 per cent at the doses of 154.4 to 175.0mg/kg for a sheep, its action was recognized to be rather in consistent. On the other hand, bithionol expelled all the tapeworms completely, its effect being checked by the fecal examination 21-29 days after the administration of 70mg/kg per sheep. The dosage of 50mg/kg showed a 100% cure rate in 2 lots of sheep and a cure rate of 92.3% in another lot, but the dosage of 30mg/kg gave a removal rate of only 60%.
Dichlorophen also expelled tapeworms completely from tested sheep which had been given a dosage of 150mg/kg. It cured 80% of the animals administered with a dose of 100mg/kg. Bithionol was also testified to be effective against M. benedeni in cows.
A combined preparation of bithionol, piperazine, and phenothiazine was used for the same purpose with considerably good results.
The toxicity of both bithionol and dichlorophen for sheep and cattle was found to be very low. The oral administration of a dose exceeding too much the curative dose would often cause a slight diarrhea, though te effective dose mentioned above produced no recognizable side reaction among sheep and cattle.
