低毒性有機燐剤による犬の毛嚢虫症治療試験

抄録

Generalized Canine demodicosis has been considered to be difficult to treat. Infested dogs were left to their fate or slaughtered with unfavorable prognosis. However, the authors applied Neguvon, a lowly toxic organo-phosphorous preparation (0, 0-di methy1-2, 2, 2-trichlor-ethylphosphonic acid ester), externally to dogs suffering from demodicosis, and found it very effective. The results obtained are as follows.
The drug was used as 0.3-1.0% solution. It was applied continually once a day until papules and pustules dried. Then the foci were lubricated with 2. 0% ointment containing 5. 0-10. 0% washed sulfur. The ointment without sulfur was used for circumscribed demodicosis.
The drug is free from harmful after-effects, so long as it is applied in the from of solution or ointment as mentioned above. When it is swallowed by a dog in large quantities, it produces symptoms of serious vagotonia in the dog.
Its lethal dose is between 200 and 500mg per kilogram of body weight. The authors do not think it effective for treatment to give infested dogs 50mg of the drug per kilogram of body weight only two or three times.