Application of an Ovine Anterior Pituitary Extract Preparation to Ovarian Cyst in Dairy Cows

Abstract

Fifty cases of Ovarian Cyst in Holstein and Jersey cows and heifers were treated with the unfractionated anterior pituitary product “Vetrophin, Abbott” (sheep origin). Twenty-seven of them had not responded to treatment with chorionic gonadotrophin within a few or several months. The doses used in this trial were 5 rat units (RU), 5 plus 5 RU, 10 RU, and 10 plus 5 RU by the intravenous route.
As a result (table 1), of 47 animals having received 5 RU, 42 recovered, but one of the 42 relapsed afterwards. Four animals which had shown no sufficient response were given an additional dose of 5 RU on the 8 th to the 18 th day after the first injection and all of them, except one recovered. Three severe cases were treated with 10 RU. Of them, one recovered, and the remaining two were injected with an additional dose of 5 RU before they showed recovery. The recovery rate in total was 90.0%(45/50). The conception rate was 81.8%(27/33) in 33 cases of breeding (table 3).
The results showed that Vetrophin was an excellent therapeutic for ovarian cyst in dairy cows or heifers. Especially it was found that 23 cases out of 27 which had been treated with chorionic gonadotrophin previously without success, recovered after Vetrophin treatment. One of them received 60, 000 MU and 5, 000 IU of chorionic gonadotrophin products within 5 months, but exhibited no sufficient response (table 2).
Five RU seemed to be an initial dose for all cases, except some apparently severe ones.
Vetrophin may be worth using for cases which have not responded to chorionic gonadotropin treatment.