Fifty cases of Ovarian Cyst in Holstein and Jersey cows and heifers were treated with the unfractionated anterior pituitary product “Vetrophin, Abbott” (sheep origin). Twenty-seven of them had not responded to treatment with chorionic gonadotrophin within a few or several months. The doses used in this trial were 5 rat units (RU), 5 plus 5 RU, 10 RU, and 10 plus 5 RU by the intravenous route. As a result (table 1), of 47 animals having received 5 RU, 42 recovered, but one of the 42 relapsed afterwards. Four animals which had shown no sufficient response were given an additional dose of 5 RU on the 8 th to the 18 th day after the first injection and all of them, except one recovered. Three severe cases were treated with 10 RU. Of them, one recovered, and the remaining two were injected with an additional dose of 5 RU before they showed recovery. The recovery rate in total was 90.0%(45/50). The conception rate was 81.8%(27/33) in 33 cases of breeding (table 3). The results showed that Vetrophin was an excellent therapeutic for ovarian cyst in dairy cows or heifers. Especially it was found that 23 cases out of 27 which had been treated with chorionic gonadotrophin previously without success, recovered after Vetrophin treatment. One of them received 60, 000 MU and 5, 000 IU of chorionic gonadotrophin products within 5 months, but exhibited no sufficient response (table 2). Five RU seemed to be an initial dose for all cases, except some apparently severe ones. Vetrophin may be worth using for cases which have not responded to chorionic gonadotropin treatment.
An outbreak and a spontaneous case of Toxascaris leonina infection were previously reported by the authors among dogs in Tokyo. After that, two additional cases of this infection were observed among dogs in different areas of the same city.Clinical experiences were detailed. Routine doses of a piperazine compound and a diphenthane-toluene complex were found effective. As in the previous experiment, 9 dogs, including puppies, were successfully infected when fed infective embryonated eggs of this parasite. The eggs began to appear in their feces 54 to 77 days after infection. Then the 9 dogs were treated experimentally with such anthelmintics as toluene, tetrachlorethylene, n-butyl-chloride, and a piperazine compound which had been employed common against Toxocara canis in dogs. As a result, tetrachlorethylene, n-butyl-chloride, and the piperazine compound, at routine doses against this parasite, showed a complete or nearly complete anthelmintic effect. This parasite had been rarely known in Japan. Nevertheless, 2 cases of this infection were revealed in a year or so, in addition to the cases reported previously by the authors. Moreover, this parasite was recovered contemporaneously in Korea and Saghalien. Therefore, a question was aroused on its distribution in Japan. A review on Japanese papers concerning helminthological surveys among dogs was presented. Several papers reported the occurrence of T. canis infection among adult dogs. The authors are of opinion that an ascarid that was really T. leonina might have been erroneously referred to as T. canis in many cases.