Abstract
Sulfadimethoxin (SD) is regarded as a new longacting sulfonamide. In this investigation, the blood level of SD was determined following the administration by six different methods in dogs. The dru also examined for was effect on the prevention of post-surgical infection in dogs.
The blood level rose very quickly to an effective extent after an intravenous, intramuscular, or subcutaneous injection of 40 mg of SD per kg of body weight. This effective level was maintained for more than 12 hours.
In the case of an oral administration of the same dose, the blood level rose slowly, reaching only 5.3 mg%, on the average, after six hours, and fell down also quite slowly.
When intravenous injections were combined with either subcutaneous or oral administration, the blood level rose quickly to an effective level, which was maintained for more than 24 hours. It was found that when an effective blood level was maintained for more than 24 hours, and when subcutaneous or oral administration was repeated every 24 hours, the effective blood level could be maintained for a long time.
Fifteen cases of Mann-Williamson's experimental operation and forty cases of ovariectomy were subjected to clinical experiments in order to determine the effect of SD on the prevention of post-surgical infection. The operative wounds were observed to the point of complete healing, and satisfactory results were obtained.
