Effect of α-Chymotrypsin upon Wounds

Abstract

1. Chemical wounds were caused artificially with concentrated sulfuric acid upon the skin of the side wall of the thorax in dogs. Then α-Chymotrypsin (CT) alone was applied locally to the wounds or administered systemically to the dogs.
2. The healing process was shorter in two treated groups than in an untreated control group.
3. The curative effect of CT seemed to be a little more excellent macroscopically in the local application than in the systemic administration. Histologically, however, there was little difference in such effect between the two methods of medication.
4. It seems that some truth may be contained both in the secondary action theory and the direct action theory to explain the anti-inflammatory action of CT.