Abstract
Methyridine, in a form of injection, was examined for anthelmintic effect on swine nematodes in laboratory trials using 13 swine.
Tric huris suis and Strongyloides ransomi were completely removed by a dose of 150 mg or more of active ingredient per kilogram of body weight. The compound showed a low efficacy against Ascaris suum even when a dose of 500 mg/kg had been administered. It seemed to have no effect on Oesophagostomum spp. It was effective to reduce the egg count of Metastrongylus apri markedly. Only a small number of these worms were detected at postmortem examination on naturally infected swine which had been treated with a dose of 250 mg/kg or more. No satisfactory results were obtained from swine artificially infected and given a dose of 250 or 300 mg/kg.
A dose of as small as 150 mg/kg given by the intraperitoneal route resulted in causing a transient, severe systemicreaction. Therefore, this procedure was not suitable for swine. When injected subcutaneously, a dose of 300 mg/kg or less gave rise to a slight systemic reaction which was intensified with a increase in dosage. Death occurred a dose of 600 mg/kg, but not at a dose of 500 mg/kg. When a dose of 300 mg/kg or less, as divided into two equal aliquots, was injected subcutaneously at sites posterior to both ears, the resulting local reaction was mild in general.
