Abstract
Bromosalicylanilide (proprietary name: Kaken D-4194) is a derivative of salicylanilide and has an anthelmintic effect on liver flukes. It was first examined for toxicity for rabbits and goats, and then for destructive effect upon naturally infected cattle.
1) A dose of 100mg/kg killed 2 rabbits 15 hours after medication. A dose of 200mg/kg killed a rabbit in 14 days, but was not lethal to another one. The fatal animals showed dyspnea and notable congestive pulmonary edema.
2) A dose of 50 or 100mg/kg was not lethal to goats. A dose of 200mg/kg killed a goat in 39 hours. The dead case revealed dyspnea and cardiac dysfunction. All the animals, killed and survived, had congestive pulmonary edema.
3) A total of 26 cattle naturally infected with liver flukes were given an oral dose of 25mg/kg. Egg examinations conducted on the 11 th-12th the 23rd-24th, and the 36th-37th day gave a negative conversion rate of 88.5, 96.2, and 96.2 per cent, respectively, as compared with the results before treatment. In appetence a decrease in milk yield, and soft feces were seen in some animals only for 1-2 days. Physical, cytological, and chemical tests were carried out in parallel. From the results of these tests, it was concluded that a dose of 25mg/kg of this drug had an excellent anthelmintic effect upon liver flukes.
