Dichlorvos (DDVP製剤) の犬消化管内寄生虫駆除効果と毒性

抄録

A single dose of 33.50×53.28mg (as effective ingredient) of dichlorvos per kg of body weight was administered to 46 dogs. The rate of complete removal was 90.0% in 30 cases of ascariasis, 94.7% in 19 cases of hookworm infection, 74.1% in 27 cases of whipworm infection, and 0% in 22 cases of tapeworm infection.
Such transient ill-effects as anorexia, depression, diarrhea of soft feces, and emesis were seen. No abortion or premautre delivery occurred to treated bitches. Cholinesterase activity began to decrease in value already an hour after medtcation, reaching a minimum at 12hours, and was 91.2% of a normal value at 120 hours. There was a tendency for erythrocyte count, hemoglobin amount, and erythrocyte volume to decrease and for the leukocyte count to increase.
When administered with three times the abovementioned dose of dichlorvos, 2 dogs manifested toxic symptoms characteristic of poisoning of organic phosphorus, but survied. In conclusion, a single dose of dichlorvos was effective against the parasites studied, except the tapeworm, in the digestive tract of the dog.