鶏伝染性気管支炎およびニューカッスル病ウイルス同時投与による干渉

抄録

1. Embryonated eggs were inoculated simultaneously with different doses of avian infectious bronchitis virus (IBV; the attenuated Nerima strain) and Newcastle disease virus (NDV; the B1 strain). In them, the propagation of one virus inoculated at the smaller dose was inhibited by the other virus inoculated at the larger dose.
2. No mutual interference was observed when 102.0-104.0 of IBV and 105.0 of NDV were incoulated simultaneously. Interference occurred when 105.0 of IBV and 105.0 of NDV were given simultaneously, and the IBV-neutralizing titer was lower than that of the control group.
3. IBV and NDV were administered at an interval of 3-10days. No interference took place when both viruses were given by nasal instillation even at an interval of 3days. Interference occurred between both viruses administered with drinking water at an interval of up to 7days.
4. Chicks bearing maternal antiby were inoculated simultaneously with both viruses. As a result, they showed only a lower IBV-neutralizing titer than those inoculated with IBV alone.
5. Chicks inoculated with IBV once at 28days of age showed a higher IBV-neutralizing titer at49days. of age than those inoculated with the same virus twice at 4 and 28days of age. Such tendency as this was not observed in NDV-neutralizing titer.