1979 Volume 32 Issue 9 Pages 494-499
Trimelarsen was injected intravenously into 246 dogs positive for microfilariae. No side effects were observed in any dog immediately after injection. The most remarkable filaricidal effect was noticed when 5mg/kg of the drug was injected four times at intervals of 4-8 hours. This effect was hardly reduced even when the drug was diluted, stored at low temperature, and used within 36 hours.
The blood level of trimelarsen reached a peak immediately after injection and decreased to about 70% 6 hours later. No residual arsenic was detected from any organ at autopsy conducted 25 days after injection.
