Abstract
The immunomodulator, Levamisole (LMS) or Klestin (PSK), was administered in dogs after experimental thoracotomy. Lymphocyte blastogenesis was depressed transiently in untreated control dogs up to 3 weeks after surgery. When 2.5mg/kg/day LMS of was administered for 3 consecutive day sper week for 2 weeks, the response of lymphocytes recoverd at the 2nd or 3rd. postoperative week. When lg/day of PSK was given for 2 weeks aftero peration, postoperative suppression of lymphocyte blastogenesis was prevented for a long time. The depressionof lymphocyte response in the PSK group recovered at the 3rd postoperative week. Neither drug influenced the number of lymphocytes or T-cells of the 11-OHCS level. LMS and PSK seemed to have efficacy on the prevention of postoperative immunosuppression, especially the depression of the lymphocyte function.
